Parish Priests
| 1822-1857 | Rev. William Thomson |
| 1857-1868 | Rev. John Gallagher |
| 1868-1871 | Rev. William Burke |
| 1871-1890 | Rev. Patrick McLaughlin |
| 1891-1894 | Rev. W J. O’Shaughnessy |
| 1894-1914 | Rev. Daniel Collins |
| 1914-1932 | Rev. John Woods |
| 1932-1965 | Rev. Joseph McHardy |
| 1965-1977 | Rev. Stephen Kennedy |
| 1977-1996 | Rev. Martin McCluskey |
| 1997- 2007 | Rev. Patrick Keegans |
| 2007- 2015 | Bishop John Cunningham |
| 14th February 2015 – 25th February 2022 | Bishop William Nolan |
| 26th February 2022 – 22nd December 2023 | Sede Vacante |
| 22nd December 2023 – (Current) | Bishop (Elect) Frank Dougan |
Cathedral Administrators
| 2007- 2016 | Rev. Patrick Keegans |
| 2015- Present | Rev. David Borland |